产品货号：
Z25807
中文名称：
SCO1抗体
英文名称：
Anti-SCO1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SCO1 Antibody |
| 指标别名 | SCO1;SCOD1;Protein SCO1 homolog;mitochondrial;MC4DN4;synthesis of cytochrome C oxidase 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | SCO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SCO1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human SCO1.The immunogen is located within amino acids 100 - 150 of SCO1. |
| 计算分子量 | 34kDa |
| 成分 | SCO1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SCO1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme,a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.Like their yeast homologs,the function of both SCO1 and SCO2 are dependent on copper ion binding.Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects,with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional,suggesting the pathology is due to loss of function.It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion,thus impairing the efficiency of copper transfer to the cytochrome c oxidase.At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody.This SCO1 antibody has no cross-reactivity to SCO2. |
| Uniprot ID | O75880 |
| 基因名全称 | SCO cytochrome oxidase deficient homolog 1 (yeast) |
| 蛋白名全称 | SCO cytochrome oxidase deficient homolog 1 (yeast) |
| 推荐稀释比 | SCO1 antibody can be used for detection of SCO1 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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